Pocket holes: fastest, weakest, most visible
A pocket-hole joint is an angled screw driven into a pilot hole. It is quick, needs one inexpensive jig, and lets a beginner build a square cabinet on the first attempt.
The trade-offs are real: the screw head is visible on the inside face unless you plug it, the joint relies on the screw rather than on wood-to-wood contact, and it moves with humidity in a way that glue joints do not.
Biscuits: best for alignment
A biscuit is a compressed beech wafer that swells in the slot when it meets glue. Its strongest suit is not strength but alignment — it stops two boards sliding out of flush during a glue-up.
Use biscuits for edge joints, mitres and attaching solid wood edging to plywood. Do not expect them to carry heavy load on their own.
Dowels: strong, cheap, invisible
Dowel joints are genuinely strong, cost very little, and disappear completely inside the wood. A well-fitted dowel joint in oak is stronger than the wood around it.
The catch is accuracy. The holes must align in both parts, which is why a self-centring dowel jig matters. With the jig, the method is reliable; without it, misalignment is almost guaranteed.
How to choose
Cabinet carcasses and shop furniture: pocket holes for speed. Edge-jointing boards into a table top or panel: biscuits for alignment plus glue. Visible furniture joints where strength matters and the joint will be seen: dowels, or a true mortise and tenon if you have the patience.
It is entirely reasonable to use all three in one project, matched to what each part needs.